Filariasis

Key Personnel:
Jim M. Kagai, HND, MSc, Biotechnologist, Senior Research Officer
Email: jkagai@kemri.org                                  

Research Interests
Improvement of diagnostic methods for parasitic diseases; Molecular diagnosis of Wuchereria bancrofti infections; Application of non-invasive procedures for diagnosis of parasitic diseases; Use of sputum and urine for diagnosis of lymphatic filariasis; Molecular epidemiology of lymphatic filariasis; Currently pursuing PhD degree studies

Publications

  1. Kagai, JM., P Muigai, PA Mbati, JI Githure, DR Koech. Use of beef extract as a diluent in direst agglutination test for visceral Leishmaniasis; East African Medical Journal; VOL.62 1992; No. 5 244-247
  2. Mbati PA, Githure JI, Kagai JM, Kirigi G, Kibati F, Wasunna K, Koech DK, Evaluation of a standardized direct agglutination Test (DAT) for the diagnosis of leishmaniasis in Kenya. Annals of Tropical Medicine and Parasitology; 1999. Vol 93 No 7, 703-710
  3. Koech, DK, Kinyanjui, MG, Kagai, JM, Wamachi, AN, Kioko E.  (1995)   Distribution of hla transplantation antigens among Kenyans of African origin and their association with disease AJHS Vol.  2
  4. Okong'o-Odera EA, Wamachi A, Kagai JM, Kurtzhals JA, Githure JI, Hey AS, Were JB, Koech DK, Mitema ES, Kharazmi A. Field application of an ELISA using redefined Leishmania antigens for the detection of visceral leishmaniasis. Trans R Soc Trop Med Hyg. 1993 87(4):423–424.
  5. Mbati, PA Obok, K, Orago, AS, Anjili, CO, Kagai, JM, Githure, JI, Koech, DK; (1994) Establishment of an appropriate innoculum dose of Leishmania donovani promastigotes required to establish a visceral infection in laboratory rodent models AJH VOL. 4  165-168
  6. Mbati PA; Abok K; Orago AS; Anjili CO; Kagai JM; Githure JI. and Koech DK. Pristane (2,6,10,14-Tetramethylpentadecane) inhibits disease progression in Leishmania-infected Balb/c mice. African Journal of Health Sciences 1994; 1(4):157-159.
  7. Mbati PA; Abok K; Anjili CO; Orago AS; Kagai JM; Githure JI. and Koech DK. Screening of metal ion chelators against Leishmania donovani-infected Syrian hamsters. African Journal of Health Sciences 1995; 2(1):223-227.
  8. Mbati PA; Abok K; Orago AS; Anjili CO; Githure JI; Kagai JM. and Koech DK. Establishment of an appropriate inoculum dose of Leishmania donovani promastigotes required to establish a visceral infection in laboratory animal rodent models. African Journal for Health Sciences 1994; 1(4):165-168
  9. Mbati, PA, Abok, K, Kagai, JM, Ndemwa, P, Koech, DK; (1992) In- vitro experimental antileishmanial potential of ethylediamine tetraacetic acid, disodium salt East African Medical Journal Vol. 69 N0. 6 35-39
  10. Schaefer KU, Kurtzhals JA, Kager PA, Gachihi GS, Gramiccia M, Kagai JM, Sherwood JA, Muller AS (1994) Studies on the prevalence of leishmanin skin test positivity in the Baringo District, Rift Valley, Kenya. Am J Trop Med Hyg 50: 78-84
  11. Kager PA, Leeuwenburg J, Kagai, JM, Muigai R, Kiugu S, Iha DW, Koech DK, and Harith A, (1989) Field application of a direct test for visceral leishmaniasis: DT HART PLENUM PUBLISHING CORP.
  12. Iha DW, Leeuwwenburg J, Kagai, JM and Koech DK, (1987) Serodiagnosis of visceral leishmaniasis KEMRI / KETRI ANNUAL MED. SC.  conference  pp133 – 135
  13. Mbati,PA., Kisia Abok, Alloys Orago, Christopher Anjili, John Githure, Jim Kagai, Davy Koech Establishment of an appropriate inoculum dose of Leishmania donovani promastigotes required to establish a visceral infection in laboratory animal rodent models.Afr J Health Sci. 1994 Nov; 1:160-164
  14. Abok, K., Christopher Anjili, Alloys Orago, Jim Kagai, John Githure, Davy Koech Screening of metal ion chelators against Leishmania donovani-infected Syrian hamsters.  Afr J Health Sci. 1995 Feb; 2:223-227
  15. Mbati, PA, Kisia Abok, Christopher Anjili, A F S. Orago, Jim Kagai, John Githure, Davy Koech Comparison of Giemsa and acridine orange stains for the diagnosis of Leishmania donovani in biopsies of infected hamsters. Afr J Health Sci. 1995 Feb; 2:228-231
  16. Abok, K,  Kagai, JM., Ndemwa, P, Koech, DK In vitro experimental antileishmanial potential of ethylenediamine tetraacetic acid, disodium salt. East Afr Med J. 1992 Jun; 69:327-332
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