CENTRE FOR RESPIRATORY DISEASES RESEARCH (CRDR) NAIROBI

Acqering samples for CD4 count using FACSCaliber

Overview

BACKGROUND

Research activities on Tuberculosis were carried out in East Africa during the early fifties, involving the three East African countries, Kenya, Uganda and Tanganyika (Tanzania) all under British rule.

The formation of East African Tuberculosis Investigation Centre was witnessed in the early 1960s under the auspices of East African Community. The present Center for Respiratory Diseases Research (CRDR) was built in the early seventies with its extension put up in 1980.

Throughout this period the Centre has distinguished itself in contributing a lot of information regarding diagnosis and treatment of Tuberculosis.

In the course of implementing its mandates to carry out research on Lung Health and other respiratory diseases, the Centre has also shed light on challenges such as Asthma, smoking problems and industrial Health. Lately, the strong association of TB and HIV, prompts the Centre to embark on work that would support both categories of patients

Mission

To apply modern science and biotechnology to discover, develop and improve tools and strategies for diagnosis, prevention and control of major human diseases in Kenya and the region

Mandate

To undertake basic and biotechnology-related research on human diseases in Kenya, with the overall goal to contribute in the improvement of human health and welfare.

Ongoing Projects

Current research in the Centre focuses on HIV/AIDS, malaria, schistosomiasis, leishmaniasis, and lymphatic filariasis. Research expertise includes molecular parasitology, molecular entomology, cellular immunology, biotechnology, biochemistry, and malacology.

Broadly speaking, research in CBRD aims to develop and improve diagnostic assays, to understand immune responses and disease processes, to characterize pathogens and their responses to chemotherapeutic interventions, to understand vector biology and ecology, develop strategies for pathogen and vector control, and to exploit biodiversity for the discovery of new drugs against diseases

Completed Projects

COMING SOON

Dr. Videlis Nduba -Deputy Director, CRDR

Dr. Videlis Nduba is a Deputy Director in charge of the Center for Respiratory Diseases Research (CRDR).
He has worked at the Institute for over 13 years with his work focusing in TB Research including developing tuberculosis epidemiological capacity to conduct phase II and III TB vaccine trials in adolescents and infants, diagnostics for infant TB, and epidemiology of TB in adolescents. He was a principal investor of a double-blind, randomised, placebo-controlled, dose-finding trial of the novel tuberculosis vaccine AERAS-402) in infants, of which Kenya was one of four countries participating in this trial.

Dr. Nduba has conducted two TB vaccine trials, one in infants and the other in adults that included bio banking protocols and extensive immunology sample collection and processing.

He has also lead a TB drug treatment trial that examined at a novel new treatment- MPaZ for shortening TB treatment from six to four months for drug sensitive TB. This research has included developing extensive networks with the TB treatment program, community networks with TB ambassadors and community health.

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Asiko Ongaya

Ms. Asiko is trained as a medical laboratory scientist (Bsc) and Mycobacteriologist (Msc) and currently undertaking a PhD studies in Microbiology. She has seven years of experience in Infectious Disease Research (especially in TB). Her research goals include to new TB diagnostics, TB drug resistance, TB drugs and to understand the protective host response to Mycobacterium tuberculosis (M.tb), especially as compromised by HIV. Ms. Asiko is currently working as Research Officer at the Centre for Respiratory Diseases Research, Kenya Medical Research Institute (KEMRI), involved in various research projects as a Principle Investigator and co-investigator.

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Dr. Jane Rahedi Ong’ang’o-Senior Research Officer

Dr. Jane Rahedi Ong’ang’o is a Public Health Specialist with interest in Programme Implementation and Operational Research of interventions geared towards control of both Communicable and Non-Communicable Conditions.
Currently she is a Senior Research Scientist at CRDR focusing on a wide scope of Public Health Research. Previously she worked as a National Programme coordinator for CDC funded HIV/TB programmes in various parts of Kenya contracted by International Medical Corps (Kenya).
In these programmes she was able to utilize community approaches to enhance scale up and use of HIV/TB services. She has been involved in implementation research and evaluation of various aspects of programme implementation. She closely works with the Ministry of Health in the National TB, Leprosy & Lung Disease Program. In the area of research, she has been a Principal investigator of various population-based surveys and has also served as a research team coordinator. In both her work areas of programme implementation and implementation research, she continues to play a role in capacity building of health workers.
Dr. Ong’ang’o has keen interest in the area of program evaluation and reviews and has previously been involved in the review of Kenya National TB program and her areas of focus are in programmatic management and Research monitoring and evaluation

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Mr. Lawrence N. Thiong’o-Research Officer

MSc in Medical Microbiology, BSc in Biomedical Sciences and Ordinary Diploma in Laboratory Technology

Involved in Clinical Trial in the comparison of two drugs Dolutegravir and Kaletra as second-line treatment in HIV-infected patients failing first line therapy-sponsored by GloxoSmithkline.

Leadership & Management in Health Sponsored by the University Of Washington.
Developed aManuscript entitled: Molecular characterization of multi-Drug resistant Escherichia coli isolated from urine samples in Mater Hospital, Nairobi, Kenya. Sent for
publication in East African Journal of Pathology (EAJP)

Involved in Family AIDS Care and Educational Services (FACES) Project. Responsible for Immunological and Microbiological work.

Principal investigator: Molecular characterization of multi- drug resistant Escherichia coli isolated from urine samples in Mater Hospital, Nairobi, Kenya

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Ms. Olga Mukasia Mashedi-Research officer

1.Academic and professional qualifications
MSc. Mycology and Bachelor Of Science in Microbiology
2.Professional/work /research experience
Mycologist area of interest in the field Respiratory Mycology
Filamentous fungi, non communicable diseases.
Research Grants/Current/Previous last three (3) years and State if PI/Co-Investigator/Support Staff
1. Principal investigator; Geomatic mapping of indoor fungi and their associated respiratory health effects in residential environments, in Nairobi and Busia urban counties-Kenya.
2. Principal investigator in Molecular characterization and antifungal drug profile of dermatophytes isolated from clinical sources in Nairobi- Kenya.
3. Principal investigator in the project titled indoor fungi and their associated health effects in residential environments in Nairobi Kenya
4. Co-investigator in the project titled: Public Mycotoxicological food safety in Kenyan Cereals.
5. Co- Investigator in the project titled: Molecular characterization and detection of Mycotoxin producing genes in mycotoxigenic fungi from Kenya cereals

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Ms. Sophie W. Matu-Research Officer

Academic and professional qualifications
B.Sc Biological Sciences (Jomo Kenyatta University- JKUAT) M.Sc Infectious Diseases Diagnosis (Kenyatta University), PhD student (Jomo Kenyatta University- JKUAT)

Professional/work /research experience
Laboratory TB diagnosis with special interest in TB/HIV co-infection, drug resistant TB and NCDs
Extra Responsibilities
Center Biosafety Officer
ISO 9001:2008 QMS officer
Member National Biosecurity Advisory Committee
Member Healthcare Waste Management -Technical Working Group (HCWM-TWG)
Member Climate Change Technical Working Group
KEMRI Climate change desk member

Selected Publications /papers presented
– Matu S.W and Ernest Juma. Improved Ziehl-Neelsen Microscopy: Bleach Sputum Smear Negative Specimens after Centrifugation. Journal of Life Sciences, ISSN 1934-7391, USA. June 2013, Vol. 7, No. 6, pp. 607-612.
– Matu S.W., Okari J., Ong’ang’o J., Kipruto H and Sitienei J. Evaluation of GenoType MTBDR for molecular detection mycobacterium tuberculosis multi-drug resistant strains at the Tuberculosis Central Reference Lab. Int J Tuberc Lung Dis 2012; 16(12) supp 1: PC-692-16.
– Okari J., Matu S.W., Ong’ang’o J., Kipruto H and Sitienei J. Drug Resistance among previously treated Pulmonary Patients in Kenya. Keystone Symposia; Drug Resistance and persistence in tuberculosis May 13-18, 2012. Poster 226.

Research Grants/Current/Previous last three (3) years
– Principle Investigator: (SSC 2948). Evaluation of the diagnostic accuracy and utility of Lateral Flow Urine Lipoarabinomannan (LAM) Test for Diagnosis of Tuberculosis in HIV-Positive presumptive TB cases
– Investigator/study coordinator: (SSC2967). A Phase IIIb, randomized, open-label study of the safety and antiviral activity of dolutegravir compared to lopinavir/ritonavir both administered with dual nucleoside reverse transcriptase inhibitor therapy in HIV-1 infected adult subjects with treatment failure on first line therapy
– Investigator/study coordinator: (SSC 2519). The burden of obstructive lung Diseases in Nairobi and its environs. Sponsor: Government of Kenya
– Research Grants/Current/Previous last three (3) years.
– State if PI/Co-Investigator/Support Staff

Contact Info

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